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KMID : 0359320030430010113
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Korean Journal of Veterinary Research
2003 Volume.43 No. 1 p.113 ~ p.120
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Antimicrobial effects of β-lactamase inhibitor/β-lactam antibiotics on staphylococcal mastitis
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임숙경/Lim, Suk-Kyung
임재향/주이석/문진산/이애리/고홍범/Lim, Jae-Hhyang/Joo, Yi-Seok/Moon, Jin-San/Lee, Ae-Ri/Koh, Hong-Bum
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Abstract
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The antimicrobial effect of β-lactam antibiotics, which had β-lactamase inhibitor activity, on Staphylococcus aureus isolated form mastitis was investigated in this study. Out of 166 isolates, 99 isolates (59.6%) produced β-lactamase, and 98 isolates of 99 were β-lactamase positive in above 12.5 ㎍/ml MIC of penicillin. In the providence distribution, β-lactamase production rate of 4 providence, Gangwon, Gyeonggi, Chungcheong, and Jeolla was 100%, 65.7%, 58.8%, and 50.0%, respectively. Antibiotic activities of β-lactam antibiotics against lactamase positive isolates also were investigated. Antimicrobial effects of ampicillin/sulbactam or amoxicillin/clavulanic acid treated group were better than ampicillin or amoxicillin treated group. In antimicrobial effects on intracellular S aureus, there was no difference 1 hour and 4 hours treatment in control, ampicillin, and amoxicillin group, but in 18 hours treatment, ampicillin/sulbactam or amoxicillin/clavulanic acid had a better effect than ampicillin or amoxicillin (p<0.05).
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